Endoscopic Tissue Adhesive for Gastric Varices

Ramond, M-J, Valla, D., Mosnier, J-F, Degott, C., Bernau., J., Rueff, B. and Benhamou, J-P. (1989) Successful Endoscopic Obturation of Gastric Varices with Butyl Cyanoacylate. Hepatology; 10: 488-493. In 27 patients who had bled from esophagogastric varices, large-sized and/or actively bleeding gastric varices were endoscopically obturated with the tissue adhesive butyl cyanoacrylate. Active bleeding was stopped in six patients. Rebleeding occurred in 10 patients; in four patients, rebleeding was due to ruptured gastric varices, occurred early and was successfully treated by reinjection of gastric varices; in one patient, rebleeding was attributed to ulceration on an injected gastric varix. Eight patients died: two of rebleeding (from esophageal varices or undetermined source), four of sepsis and/or liver failure and two at home of undetermined cause. No specific complication due to injection of gastric varices was observed. The results obtained in this series of patients with gastric varices obturated by injection of butyl cyanoacrylate are much more satisfactory than those obtained in previously published series of patients with gastric varices treated by injection of sclerosants. HPB INTERNATIONAL 215